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The Gordian Platform

THE most patient-predictive in vivo experiments, at a scale previously thought impossible.

Silhouette of a person and a horse beside a visual representation of data and a cell

I. Patient Avatars

Representative models

Patient Avatars are animals that most closely represent human patients with our target indications and have often acquired the disease naturally.

Silhouette of a person with highlighted liver and knee, next to a horse silhouette with highlighted knee and monkey silhouette with highlighted liver

Gene therapy is fulfilling the promise of miracle cures for rare diseases. But even as delivery technology continues to mature, the field has yet to make headway for much more common complex diseases because of target risk. At Gordian, we leverage proven gene therapy delivery technology to screen thousands of targets for these complex diseases, eliminating this barrier.

Chris Towne VP of Gene Therapy
A portrait of Chris Towne.

II. Mosaic Screening

Pooled in vivo experiments

We create a pooled library of thousands of therapies and test them in vivo in individual Patient Avatars. The target tissue becomes a mosaic, where in each therapy modifies thousands of cells.

Slice of liver at cellular level with highlighted sections depicting Therapy A, B, and C, impacting individual cells

At Gordian, our culture has a single driver: enabling all Gors to do their best work. We craft operational processes that increase productivity, and delete those that do the opposite. We focus benefits on handling as many of life’s concerns as possible. We ensure Gordian goals and the personal goals of every team member are aligned through designed incentive structures and transparent communication between all individuals, regardless of role.

Bharath Kumandan VP of Operations
A portrait of Bharath Kumandan.

III. Pythia

Predictive transcriptome analysis

Instead of focusing on a single hypothesis for disease, Gordian’s Pythia examines the entire transcriptome of modified cells to examine how each of these therapies affects dozens of cellular pathways in the living animal.

Slice of liver at cellular level with highlighted sections depicting Therapy A, B, and C, impacting individual cells

Learn more about our science